A population pharmacokinetic pk analysis for insulin detemir idet in children from 1 to less than 18 years of age, compared to adults, all with t1dm. Insulin loses potency when exposed to extreme temperatures which can result in loss of blood glucose control. Ideg is reported to have a terminal halflife of approximately 25 hours, which is two times longer than insulin. You can inject from 1 to 80 units in a single injection. Insulin detemir in the treatment of type 1 and type 2 diabetes ncbi. Insulin glargine lantus to insulin detemir levemir convert unit per unit. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. T o p 1 0 l i s t o f s a f e t y t i p s f o r l e v e m i r brought to you by the institute for safe medication practices read this important information before taking. Levemir, inninsulin detemir european medicines agency europa. Objective to assess whether initiation of insulin glargine glargine, compared with initiation of nph or insulin detemir detemir, was associated with an increased risk of breast cancer in women with diabetes. Effects of insulin detemir and nph insulin on body weight. Capitals indicate lifethreatening, underlines indicate most frequent. Scientific discussion on changes after approval please.
Insulin pharmacology, therapeutic regimens, and principles of. Insulin detemir side effects, dosage, uses, and more. Insulin detemir is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours insulin detemir is used to improve blood sugar control in adults and children with diabetes mellitus insulin detemir. The first page of the pdf of this article appears above. Selles selgitatakse, kuidas inimravimite komitee hindas ravimit ja. If using a new vial, pull off the plastic protective cap, but do not remove the rubber stopper 2. Learn about side effects, warnings, dosage, and more. Insulin detemir is a soluble, longacting basal human insulin analog with a relatively flat action profile. Levemir is a longacting basal insulin analog manufactured by novo nordisk. Research design and methods this was a retrospective newuser cohort study of female medicare beneficiaries aged. Insulin detemir has been studied in human pregnancy. Effects of insulin detemir and nph insulin on body weight and appetiteregulating brain regions in human type 1 diabetes. Insulin detemir is a new basal insulin analogue recently available for commercial use in the uk.
Insulin detemir is a soluble longacting human insulin analogue at neutral ph with a unique mechanism of action. Evaluation of unit equivalency of insulin glargine to insulin detemir. Clinical trials have demonstrated lower fasting plasma glucose levels, lower variability in plasma glucose. Insulin detemir differs from human insulin in that the amino acid threonine in position b30 has been omitted, and a c14 fatty acid chain has been attached to the amino acid b29. Insulin glargine detemir insulin glargine detemir recently, insulin degludec ideg, a new, longacting basal insulin preparation, has been made commercially available. A comparative, randomized pilot study of insulin glargine versus insulin detemir as addon therapy in uncontrolled type 2 diabetic patients. Insulin detemir versus insulin glargine in the hospital. Similar breast cancer risk in women older than 65 years.
Insulin is a drug prescribed to treat type 1 and type 2 diabetes. Insulin detemir versus insulin glargine for type 2. Cost analysis of insulin degludec in comparison with insulin detemir. Levemir vial insulin detemir injection 100 unitsml. A new, longacting insulin analog modified, synthetic form of insulin that acts in the bloodstream for up to 24 hours. Several studies have compared either insulin detemir or insulin glargine to nph neutral protamin hagedorn insulin. Insulin detemir in the treatment of type 1 and type 2 diabetes. Insulin detemir is a long acting human analogue insuline, that allows insulin detemir to reversibly bind to albumin, prolonging its action. Administer daily insulin detemir with evening meal or at bedtime. Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in the insulin dose or an adjustment of concomitant antidiabetic treatment. Insulin is a hormone that works by lowering levels of glucose sugar in the blood. Insulin detemir is used with a proper diet and exercise program to control high blood sugar in people with diabetes.
Once properly stored insulin becomes available, insulin. An openlabel longitudinal study on the efficacy of. Patientfamilyteaching instruct patient on proper technique for administration. The insulin analogs, insulin glargine and insulin detemir, were introduced in an attempt to improve glycemic control among patients with diabetes. Insulin glargine was dosed oncedaily in the evening. Insulin detemir levemir is an injectable medication used to treat type 1 and type 2 diabetes. Insulin detemir is a neutral, soluble, longacting insulin analogue in which threonine is omitted from position b30 of the insulin.
Levemir is a clear, colourless, neutral solution of insulin detemir. Insulin detemir is a new longacting insulin analog. With respect to blood sugar management, it appears to work at least as well as nph insulin and insulin glargine. One unit u of insulin detemir corresponds nominally to one iu international unit of human insulin. Insulin therapy is the cornerstone of diabetes therapy, and the use. Levemir insulin detemir rdna origin dose, indications. Levemir is designed to provide 24hour blood sugar control and to lower the a1c in those with type 1 and type 2 diabetes insulin detemir. Pdf diabetes mellitus is a growing public health concern in the us and worldwide. Article information, pdf download for evaluation of unit equivalency of insulin. Insulin detemir is characterized by a consistent pharmacokinetic. Since then, numerous formulations with various similar names have been produced and marketed. Insulin detemir, the active ingredient in levemir, is an insulin analogue with a prolonged duration of action, and is produced by recombinant dna technology using a genetically modified strain of saccharomyces cerevisiae. Insulin detemir levemir is a longacting insulin analog in which the b30 amino acid is omitted and a c14 fatty acid chain myristic acid is bound.
Insulin detemir versus insulin glargine for type 2 diabetes mellitus. This fatty acid modification allows insulin detemir. Insulin detemir use is associated with higher occurrence of. Levemir insulin detemir is a long lasting insulin that provides consistent, allday blood sugar control with less risk of low blood sugar. Insulin detemir produces a more predictable dosing profile than nph insulin. See on ravimi levemir euroopa avaliku hindamisaruande kokkuvote. Insulin detemir, sold under the brand name levemir among others, is a longacting insulin used to treat both type 1 and type 2 diabetes. There is clearly a lower withinsubject variability of insulin effect with insulin detemir. Common side effects include headache, nausea, tiredness, blurred vision, and excessive yawning. Find patient medical information for insulin detemir u100 subcutaneous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Doses can be easily adjusted to make a customized regimen thats. Insulin detemir is a longacting basal insulin analog, with up to 24 hours duration of action. Marketed under the brand name levemir, detemir is approved for.
Use of insulin detemir and insulin glargine during pregnancy. Treatment with insulin detemir once or twice daily was compared to nph insulin once, twice, or three times per day in an openlabel clinical trial. Pdf a 52yearold insulindependant diabetic man presented to the emergency department 2. Insulin detemir was initiated oncedaily in the evening with the option of an additional dose in the morning in three studies and initiated twicedaily in one study. The mean duration of action of insulin detemir ranged from 5. Insulin detemir is an acylated insulin analog with threonine removed at position b30, and lysine at position b29 is acylated with a 14carbon myristoyl fatty acid acylation, resulting in delayed. Maternal efficacy and safety outcomes in a randomized controlled trial comparing insulin detemir with nph insulin. We report cases of three patients affected by type 1 diabetes, who developed ecchymosis at injection site after administration of insulin detemir.
From the published phase iii trials, the effect of insulin detemir as a basal insulin is the same or better in comparison with nph in terms of achieving glycemic control estimated by hba1c. In studies in healthy volunteers, insulin detemir produced a linear and doseproportional. Hold the syringe with the needle pointing up in the air and. Administer twice daily insulin detemir evening dose with evening meal, at bedtime, or 12 hrsaftermorningdose. Levemir vial insulin detemir injection 100 unitsml 2 1. Sections or subsections omitted from the full prescribing information are not listed. The aim was to compare the efficacy and safety of insulin glargine versus insulin detemir as addon therapy in type 2 diabetes patients inadequately controlled on oral hypoglycemic agents. Needymeds has free information on medication and healthcare costs savings programs including prescription assistance programs and medical and dental clinics. The two longacting insulin analogues artificial insulins, insulin detemir or insulin glargine differ in their mechanism of attaining protracted. Though generally well tolerated, injection site reactions have been reported in 2% of insulin detemir users.